Discovery of lambda-lactam derivatives containing 1,3-benzodioxole unit as potential anti-phytopathogenic fungus agents

文献类型： 外文期刊

第一作者： Song, Di

作者： Song, Di;Cao, Xiufang;Wang, Jingjing;Ke, Shaoyong

作者机构：

关键词： gamma-Lactam; 1,3-Benzodioxole; Diversity-oriented; Antifungal activities; Agricultural fungi

期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）

ISSN： 0960-894X

年卷期： 2020 年 30 卷 2 期

页码：

收录情况： SCI

摘要： A series of gamma-lactam analogs containing 1,3-benzodioxole moiety were designed, and these derivatives were synthesized from the lead compound of lactam via a structural diversity-oriented synthesis, their structures were confirmed by (HNMR)-H-1, (CNMR)-C-13, ESI-MS spectrum. Their antifungal activities were evaluated against four serious and typically crop-threatening agricultural fungi, including Rhizoctonia solani, Alternaria tenuis Nees, Gloeosporium theae-sinensis, and Fusarium graminearum. Some of these derivatives exhibited activity against Alternaria tenuis Nees higher than that of commercial fungicides carbendazim, such as compounds 7a, 7b, and 7i, compared with the blank control, some of these derivatives showed good antifungal activities against Gloeosporium theae-sinensis and Fusarium graminearum. The systematic study provides evidences for further structural modification and application of lactam analogues as antifungal agents for agriculture.

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