A Neuroinflammation Inhibitor, Hypoxylon xanthone A, from Soil Fungus Hypoxylon sp.

文献类型： 外文期刊

第一作者： Xiao, Ying

作者： Xiao, Ying;Xu, Bing;Li, Yuedi;Kang, You;Cui, Yong;Liu, Wei;Xiang, Zheng

作者机构：

关键词： Soil fungus Hypoxylon sp.; metabolite; NMR spectrum; ECD; chemical constituent; anti-neuroinflammatory

期刊名称：LETTERS IN ORGANIC CHEMISTRY （ 影响因子：0.867； 五年影响因子：0.865 ）

ISSN： 1570-1786

年卷期： 2020 年 17 卷 2 期

页码：

收录情况： SCI

摘要： Hypoxylon sp. was used to ferment at 25 degrees C for 45 days. The solid culture of Hypoxylon sp. was extracted with 75% EtOH under ultrasonic for twice. And the dried combined extracts were then suspended in H2O and partitioned with ethyl acetate. EtOAc extracts were subjected to a silica gel column and eluted with petroleum ether - acetone to afford seven fractions. Sephadex LH-20 and RP-HPLC were used subsequently to yield a novel xanthone metabolite (Hypoxylon xanthone A). Its structure was elucidated based on HR-ESI-MS, 1D-, 2D-NMR spectra, and the comparison of the experimental and calculated ECU spectra. The anti-neuroinflammatory assay of Hypoxylon xanthone A, as manifested by the inhibitory effect on LPS-induced NO production in BV-2 microglial cells, indicated almost the same inhibitory effect as minocycline in a dose-dependent manner within the concentration of 1-50 mu M, suggesting that Hypoxylon xanthone A could be a new potential neuroinflammation inhibitor.

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