Isotope-labeled internal standards and grouping scheme for determination of neonicotinoid insecticides and their metabolites in fruits, vegetables and cereals - A compensation of matrix effects

文献类型： 外文期刊

第一作者： Wu, Changcai

作者： Wu, Changcai;Dong, Fengshou;Mei, Xiangdong;Ning, Jun;She, Dongmei

作者机构：

关键词： Neonicotinoid insecticides; Metabolites; Isotope-labeled internal standard method; Matrix effects

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN： 0308-8146

年卷期： 2020 年 311 卷

页码：

收录情况： SCI

摘要： Neonicotinoid insecticides (NIs) are widely used. However they produce high levels of residues and are toxic to non-target organisms, especially when their metabolites exhibit comparable or elevated toxicities. In this study, we established a multi-residue analytical method for analyzing 20 compounds - 8 NIs and their 11 major toxic metabolites. QuEChERS pretreatment and ultra-high-performance liquid chromatography-tandem mass spectrometry were used to detect residues in fruits, vegetables and cereals. Determination time was shortened to 6 min. Average recoveries of all compounds were in the range of 90.1-105.5%, with relative standard deviations lower than 15.0% and the limit of quantization being 10 mu g kg(-1). For the first time, 8 NIs and 11 major toxic metabolites were grouped simultaneously, such that the matrix effect of analyzes was satisfactorily corrected using their own isotopically labeled molecules; other NIs and metabolites in the same group were also corrected. This is the first report that simultaneously quantified multiple metabolites of eight NIs in multiple matrices.

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