文献类型： 外文期刊
第一作者： Yu, Shu-Juan
作者： Yu, Shu-Juan;Yu, Zhi-Pu;Yan, Xue;Yu, Shu-Juan;Yu, Jin-Hai;Yu, Zhi-Pu;Yan, Xue;Zhang, Jun-Sheng;Zhang, Hua;Sun, Jin-yue
作者机构：
关键词： Eclipta prostrata; Compositae; Terpenoid; alpha-glucosidase; Cytotoxicity; Antibacterial
期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）
ISSN： 0031-9422
年卷期： 2020 年 170 卷
页码：
收录情况： SCI
摘要： Chemical fractionation of the ethanolic extract of Eclipta prostrata yielded a series of unreported terpenoid constituents, including a rare 6/6/6/6-fused tetracyclic triterpenoid, a pentacyclic triterpenoid, two pentacyclic triterpenoid saponins, a diterpenoid and a sesquiterpenoid. Structures were assigned to these compounds on the basis of comprehensive spectroscopic analyses, with the absolute configurations of the tetracyclic triterpenoid, the diterpenoid and the sesquiterpenoid being determined via explanation of electronic circular dichroism data. Screening of these isolates in an array of bioassays revealed antibacterial, cytotoxic and alpha-glucosidase inhibitory activities for selective compounds. Of particular interest, the tetracyclic triterpenoid showed very strong inhibition against alpha-glucosidase with an IC50 of 0.82 +/- 0.18 mu M, being 10(3)-fold as active as the positive control acarbose.
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