Formation of bioactive peptides during simulated gastrointestinal digestion is affected by alpha(s1)-casein polymorphism in buffalo milk

文献类型： 外文期刊

第一作者： Li, Shanshan

作者： Li, Shanshan;Chen, Chen;Liu, Jianxin;Ren, Daxi;Li, Shanshan;Hu, Qi;He, Guoqing;Li, Shanshan;Hu, Qi;He, Guoqing;Wu, Jianping;Wu, Jianping;Li, Ling

作者机构：

关键词： Buffalo milk; alpha(s1)-casein polymorphism; Gastrointestinal digestion; Bioactive peptides

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN： 0308-8146

年卷期： 2020 年 313 卷

页码：

收录情况： SCI

摘要： The polymorphism of buffalo alpha(s1)-casein has been reported, but little is known about their effect on the biological properties. The objective of this study was to investigate the effect of alpha(s1)-casein polymorphism on the digestive properties and bioactivities of buffalo milk protein in simulated gastrointestinal digestion. In this study, two variants of alpha(s1)-casein, with one amino acid substitution of Leu193 (AA) -> Ser193 (BB), were used. Under acidic gastric conditions, the particle size of alpha(s1)-casein variant BB was smaller and showed higher digestibility compared to variant AA. A total of 154 and 149 peptides were identified, respectively, from simulated gastrointestinal digestion of variants AA and BB; of three peptides have been previously reported to exert ACE-inhibition, anticancer, antioxidant, and anxiolytic activities. Our study demonstrated that alpha(s1)-casein polymorphism affects the digestive properties and the formation of bioactive peptides.

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