Dual-target electrochemical aptasensor based on co-reduced molybdenum disulfide and Au NPs (rMoS(2)-Au) for multiplex detection of mycotoxins

文献类型： 外文期刊

第一作者： Han, Zheng

作者： Han, Zheng;Tang, Zhanmin;Jiang, Keqiu;Huang, Qingwen;Meng, Jiajia;Nie, Dongxia;Zhao, Zhihui;Tang, Zhanmin

作者机构：

关键词： Co-reduced molybdenum disulfide and Au NPs (rMoS(2)-Au); Electrochemical aptasensor; Zearalenone; Fumonisin B1

期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：10.618； 五年影响因子：9.323 ）

ISSN： 0956-5663

年卷期： 2020 年 150 卷

页码：

收录情况： SCI

摘要： Multiple mycotoxin contamination has posed health risks in the area of food safety. In this study, co-reduced molybdenum disulfide and gold nanoparticles (rMoS(2)-Au) were designed and used for the first time as an efficient platform endowing electrochemical electrodes with superior electron transfer rates, large surface areas and strong abilities to firmly couple with large amounts of different aptamers. After further modification with thionine (Thi) and 6-(Ferrocenyl) hexanethiol (FC6S), a platform enabling sensitive, selective and simultaneous determination of two important mycotoxins, zearalenone (ZEN) and fumonisin B1 (FB1), was achieved. The established aptasensor showed excellent linear relationships (R-2 > 0.99) when ZEN and FB1 concentrations were in the range of 1 x 10(-3) -10 ng mL(-1) and 1 x 10(-3) -1 x 10(2) ng mL(-1), respectively. High sensitivity of ZEN and FB1 with a limit of detection as low as 5 x 10(-4) ng mL(-1) was obtained with excellent selectivity and stability. The effectiveness of the aptasensor was verified in real maize samples, and satisfactory recoveries were attained. The established platform could be easily expanded to other aptamer-based multiplex screening protocols in biochemical research and clinical diagnosis.

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