Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis

文献类型： 外文期刊

第一作者： Xu, Xiaocui

作者： Xu, Xiaocui;Li, Guoqiang;Li, Congru;Zhang, Jing;Chen, Xuepeng;Zhu, Wei;Liu, Jiang;Xu, Xiaocui;Li, Congru;Chen, Xuepeng;Zhu, Wei;Liu, Jiang;Wang, Qiang;Simmons, David K.;Wijesena, Naveen;Martindale, Mark Q.;Wang, Zhanyang;Wang, Zhenhua;Ju, Bao;Ci, Weimin;Lu, Xuemei;Wang, Qian-fei;Yu, Daqi;Zhang, Yong E.;Aluru, Neelakanteswar;Oliveri, Paola;Oliveri, Paola;Liu, Jiang

作者机构：

关键词： DNA methylation; evolution; development; reprogramming

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：17.275； 五年影响因子：17.584 ）

ISSN： 2095-5138

年卷期： 2019 年 6 卷 5 期

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收录情况： SCI

摘要： Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates and vertebrates, with numerous spectacular innovations. To search for the molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans. We focused on gametes and early embryos, where the methylomes are known to evolve divergently between fish and mammals. Here, we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects, but clearly presents in deuterostomes such as echinoderms and invertebrate chordates, and then becomes more evident in vertebrates. Functional association analysis suggests that DNA methylation reprogramming is associated with development, reproduction and adaptive immunity for vertebrates, but not for invertebrates. Interestingly, the single HOX cluster of invertebrates maintains unmethylated status in all stages examined. In contrast, the multiple HOX clusters show dramatic dynamics of DNAmethylation during vertebrate embryogenesis. Notably, the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals. Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution, especially after the evolutionary transitions from invertebrates to vertebrates, and then to mammals.

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