Cross protection induced by combined Subolesin-based DNA and protein immunizations against adult Haemaphysalis longicornis

文献类型： 外文期刊

第一作者： Hassan, Ibrahim A.

作者： Hassan, Ibrahim A.;Wang, Yanan;Zhou, Yongzhi;Cao, Jie;Zhang, Houshuang;Zhou, Jinlin

作者机构：

关键词： Anti-tick vaccine; Subolesin; Ribosomal P0; DNA vaccine; Chimeric polypeptide

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2020 年 38 卷 4 期

页码：

收录情况： SCI

摘要： Vaccination against ticks is an environmentally friendly alternative control method compared to chemical acaricide applications. Subolesin is a conserved protein in ticks, which can provide protection against some tick species. In this study, we evaluated the capacity of cocktail vaccination with Subolesin and ribosomal acidic protein 0 (P0) peptide against adults of Haemaphysalis longicornis. Priming with DNA vaccine expressing subolesin, followed by boosters of a single antigen (rRhSub) or a chimeric polypeptide (rRhSub/P0), provided cross protection. This treatment resulted in significant mortality, reduced blood ingestion and reduced reproduction in H. longicornis adults. Vaccination efficacies of 79.3% and 86.6% are reported in groups supplemented with rRhSub and rRhSub/P0, respectively. Conserved antigens, such as subolesin, formulated as DNA vaccine and enhanced with chimeric polypeptides, could be used as an anti-tick vaccine application, especially for control of infestation involving several tick species. (C) 2019 The Author(s). Published by Elsevier Ltd.

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