Identification of genes related to resistance against S. Typhimurium in ovine macrophages

文献类型： 外文期刊

第一作者： Wang, Mengyao

作者： Wang, Mengyao;Yang, Dongbing;Liu, Zhexi;Wei, Shao;Wang, Linli;Ai, Yue;Han, Hongbing;Wang, Mengyao;Yang, Dongbing;Liu, Zhexi;Wei, Shao;Wang, Linli;Ai, Yue;Han, Hongbing;Wang, Mengyao;Yang, Dongbing;Liu, Zhexi;Wei, Shao;Wang, Linli;Ai, Yue;Han, Hongbing;Zhang, Xiaosheng

作者机构：

关键词： Sheep; Macrophage; S. Typhimurium; RNA-seq

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2020 年 139 卷

页码：

收录情况： SCI

摘要： Salmonella enteric serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen causing public health hazards. Identification of genes related to macrophages resistance to S. Typhimurium and their immune mechanisms can provide a theoretical basis for disease resistance. In this study, sixty significant differentially expressed genes were screened between susceptible and resistant sheep macrophages by transcriptome RNA-seq. Eight significantly enriched GO terms and six canonical pathways were involved by GO and KEGG enrichment analysis. Furthermore, knockdown of HMOX1 and SLPI increased remarkably the clearance of S. typhimurium, but SPP1 had little effect on the clearance of S. Typhimurium within sheep macrophages. Altogether, these results suggest that many genes of macrophages were reprogrammed via S. Typhimurium infection, some of which may facilitate host defence against Salmonella, while others allow Salmonella to escape.

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