Proteome of thymus and spleen reveals that 10-hydroxydec-2-enoic acid could enhance immunity in mice

文献类型： 外文期刊

第一作者： Fan, Pei

作者： Fan, Pei;Han, Bin;Hu, Han;Wei, Qiaohong;Zhang, Xufeng;Meng, Lifeng;Li, Jianke;Fan, Pei;Tian, Xinyue;Zhang, Lu;Nie, Jing;Tang, Xiaofeng;Wang, Liping

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关键词： 10-HDA; mouse; proteome; spleen; thymus

期刊名称：EXPERT OPINION ON THERAPEUTIC TARGETS （ 影响因子：6.902； 五年影响因子：6.06 ）

ISSN： 1472-8222

年卷期： 2020 年 24 卷 3 期

页码：

收录情况： SCI

摘要： Objectives: 10-hydroxydec-2-enoic acid (10-HDA), a unique component of royal jelly existing only in nature, has the potential to promote human health. Knowledge of 10-HDA in regulating immuno-activity, however, is lacking. The aim of our work is to gain a novel understanding of 10-HDA in promoting immunity. Methods: Immuno-suppressed mice were generated by cyclophosphamide injection, After 10-HDA supplementation to the mice to rescue their immunity, the proteomes of the thymus and spleen were analyzed. Results: The weight of the body, thymus, and spleen in cyclophosphamide-induced mice recovered by 10-HDA indicate its potential role in immuno-organ protection. In the thymus, the enhanced activity of pathways associated with DNA/RNA/protein activities may be critical for T-lymphocyte proliferation/differentiation, and cytotoxicity. In the spleen, the induced pathways involved in DNA/RNA/protein activities, and cell proliferative stimulation suggest their vital role in B-lymphocyte affinity maturation, antigen presentation, and macrophage activity. The up-regulated proteins highly connected in networks modulated by 10-HDA indicate that the mice may evolve tactics to respond to immuno-organ impairment by activating critical physiological processes. Conclusion: Our data constitute a proof-of-concept that 10-HDA is a potential agent to improve immunity in the thymus and spleen and offer a new venue for applying natural products to the therapy for hypoimmunity.

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