Von Willebrand Factor Deficiency Improves Hepatic Steatosis, Insulin Resistance, and Inflammation in Mice Fed High-Fat Diet

文献类型： 外文期刊

第一作者： Yang, Juan

作者： Yang, Juan;Lu, Yan;Lou, Xudan;Wang, Haidong;Yang, Juan;Lu, Yan;Lou, Xudan;Bao, Zhijun;Wang, Haidong;Wang, Jian;Yu, Huilin;Yu, Huilin;Bao, Zhijun;Bao, Zhijun;Bao, Zhijun

作者机构：

期刊名称：OBESITY （ 影响因子：5.002； 五年影响因子：5.251 ）

ISSN： 1930-7381

年卷期： 2020 年 28 卷 4 期

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收录情况： SCI

摘要： Objective The aim of this study was to investigate the effect of Von Willebrand factor (VWF) on high-fat diet (HFD)-induced hepatic steatosis, insulin resistance, and inflammation in mice. Methods The expression of VWF was detected in obese mice. Wild-type and VWF knockout mice were fed a normal chow diet or an HFD, and then biomedical, histological, and metabolic analyses were conducted to identify pathologic alterations. Inflammatory cytokine levels and the number of hepatic macrophages were determined in these mice fed an HFD. Results VWF expression was significantly increased in obese mice. VWF-/- mice were less obese and had improved hepatic steatosis, balance of lipid metabolism, and insulin resistance in response to HFD. Furthermore, VWF deficiency attenuated HFD-induced systemic and hepatic inflammation. In addition, VWF deficiency rescued the abnormal accumulation of hepatic macrophages. Conclusions These data demonstrated VWF deficiency improves hepatic steatosis, insulin resistance, and inflammation. Furthermore, the protective effects are mediated via regulation of hepatic macrophages.

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