Multiple association analysis of loci and candidate genes that regulate body size at three growth stages in Simmental beef cattle

文献类型： 外文期刊

第一作者： Wang, Xiaoqiao

作者： Wang, Xiaoqiao;Miao, Jian;Chang, Tianpeng;Xu, Lingyang;Zhang, Lupei;Li, Junya;Gao, Huijiang;Xia, Jiangwei;Song, Meihua;Ni, Junqing

作者机构：

关键词： Simmental beef cattle; Genome-wide association studies; Body size; Candidate genes; Bovine HD 770K SNP

期刊名称：BMC GENETICS （ 影响因子：2.797； 五年影响因子：3.263 ）

ISSN： 1471-2156

年卷期： 2020 年 21 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundBody size traits as one of the main breeding selection criteria was widely used to monitor cattle growth and to evaluate the selection response. In this study, body size was defined as body height (BH), body length (BL), hip height (HH), heart size (HS), abdominal size (AS), and cannon bone size (CS). We performed genome-wide association studies (GWAS) of these traits over the course of three growth stages (6, 12 and 18months after birth) using three statistical models, single-trait GWAS, multi-trait GWAS and LONG-GWAS. The Illumina Bovine HD 770K BeadChip was used to identify genomic single nucleotide polymorphisms (SNPs) in 1217 individuals.ResultsIn total, 19, 29, and 10 significant SNPs were identified by the three models, respectively. Among these, 21 genes were promising candidate genes, including SOX2, SNRPD1, RASGEF1B, EFNA5, PTBP1, SNX9, SV2C, PKDCC, SYNDIG1, AKR1E2, and PRIM2 identified by single-trait analysis; SLC37A1, LAP3, PCDH7, MANEA, and LHCGR identified by multi-trait analysis; and P2RY1, MPZL1, LINGO2, CMIP, and WSCD1 identified by LONG-GWAS.ConclusionsMultiple association analysis was performed for six growth traits at each growth stage. These findings offer valuable insights for the further investigation of potential genetic mechanism of growth traits in Simmental beef cattle.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序