Two new diterpenoids with their antiproliferative activities from the supercritical fluid extraction of Croton crassifolius root

文献类型： 外文期刊

第一作者： Liu, Chao

作者： Liu, Chao;Zhang, Rui-rui;Zhang, Jing;Wang, Mu-xuan;Meng, Na-na;Wang, Qing;Sun, Jin-yue;Wang, Wen-liang;Niu, Qing-lin

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关键词： Croton crassifolius; diterpenoid; antiproliferative

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

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收录情况： SCI

摘要： Supercritical fluid extraction was applied to obtain the lower polarity extracts from Croton crassifolius roots, and chemical investigation of which led to the isolation and identification of two new diterpenoids, named crassifolius P (1) and crassifolius Q (2). In vitro anti-proliferative activities of compounds 1 and 2 on A549, Hep-G2 and Hela tumor cell lines were evaluated. The two new compounds exhibited obvious selectivity to tumor cells with IC50 values ranging from 20.43 +/- 1.18 mu M to 25.72 +/- 1.32 mu M.

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