beta-carotene as a dietary factor affecting expression of genes connected with carotenoid, vitamin A and lipid metabolism in the subcutaneous and omental adipose tissue of beef cattle

文献类型： 外文期刊

第一作者： Wei, C.

作者： Wei, C.;Tan, X.;Liu, G.;Wan, F.;Zhao, H.;You, W.;Liu, X.;Zhang, X.;Jin, Q.;Zhang, C.

作者机构：

关键词： adipose tissue; beef cattle; beta-carotene; gene expression; lipid metabolism

期刊名称：JOURNAL OF ANIMAL AND FEED SCIENCES （ 影响因子：1.525； 五年影响因子：1.625 ）

ISSN： 1230-1388

年卷期： 2020 年 29 卷 1 期

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收录情况： SCI

摘要： Adipose tissue in meat, especially subcutaneous fat, is not appreciated by consumers as it is considered unhealthy. The effects of beta-carotene (beta C) on the expression of ten genes related to carotenoid, vitamin A (VA) or lipid metabolism were evaluated in subcutaneous and omental (visceral) adipose tissue of Simmental crossbred steers receiving various beta C treatments (0, 600, 1200 and 1800 mg/d). Two carotenoid oxidative cleavage genes (beta-carotene-15,15'-monooxygenase (BCMO1) and beta-carotene-9',10'-dioxygenase (BCO2)) were up-regulated and three VA metabolic genes (retinoid X receptor a (RXRA), retinal reductase (RALDH) and lecithin-retinol acyltransferase (LRA7)) were down-regulated in subcutaneous and omental adipose tissues. Gene encoding peroxisome proliferator-activated receptor gamma (PPARG) involved in adipocyte differentiation and lipogenesis was down-regulated in both examined fat tissues. For the omental adipose tissue, the lipogenesis gene (fatty acid synthase (FAS)) and the two lipolysis genes (hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL)) were down-regulated, but another lipogenesis gene (acetyl-CoA carboxylase (ACC)) was up-regulated. First of all, the addition of beta C in the det may inhibit the expression of the major adipogenesis gene - PPARG, and increase the expression of genes involved in beta C catabolism in adipose tissue of beef cattle. An effective beta C dose to regulate the expression of genes connected with carotenoid, VA and lipid metabolism would be at least 600 mg/d.

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