The Twice-Oxidized Graphene Oxide/Gold Nanoparticles Composite SERS Substrate for Sensitive Detection of Clenbuterol Residues in Animal-Origin Food Samples

文献类型： 外文期刊

第一作者： Cheng, Jie

作者： Cheng, Jie;Fan, Mengdie;Wang, Peilong;Su, Xiao-Ou

作者机构：

关键词： Clenbuterol; Liquid-liquid extraction; Surface-enhanced Raman spectroscopy; Animal-origin food sample; Detection

期刊名称：FOOD ANALYTICAL METHODS （ 影响因子：3.366； 五年影响因子：3.07 ）

ISSN： 1936-9751

年卷期： 2020 年 13 卷 4 期

页码：

收录情况： SCI

摘要： The illegal use of clenbuterol (CL), as a growth promoter in animal feeding, is banned in the majority of countries across the world, such as the European Union and China. In this study, a rapid and sensitive method for detecting CL in animal-origin food samples based on liquid-liquid extraction and surface-enhanced Raman spectroscopy (SERS) has been developed for the first time. A twice-oxidized graphene oxide/gold nanoparticles composite substrate was innovatively synthesized and used to enhance the characteristic Raman signal of CL at ov = 1474 cm(- 1) and 1608 cm(- 1), and no more than 10 min of sample cleanup was required before SERS analysis. The optimized hybrid substrate demonstrated good stability over a period of 240 days, which is more stable than previous studies. Quantitation calculation was performed in the concentration range of 1-100 ng g(- 1) with a limit of detection (LOD) as low as 1 ng g(- 1). Furthermore, the novel detection method was verified for use in the identification of real samples, and the results were consistent with those of liquid chromatography-tandem mass spectrometry (LC-MS/MS). The simplicity and reliability of the proposed method demonstrate its great potential for practical applications in the field of quality control and food safety.

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