Syringin protects against colitis by ameliorating inflammation

文献类型： 外文期刊

第一作者： Zhang, Haihua

作者： Zhang, Haihua;Jia, Qinghui;Li, Hongqiang;Shen, Shurui;Liu, Xin;Shi, Qiumei;Gu, Haijun;Zhao, Yanqing;Wang, Guisheng

作者机构：

关键词： Syringin; Colitis; Inflammation; NF-kappa B pathway; Nrf2 pathway

期刊名称：ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS （ 影响因子：4.013； 五年影响因子：4.076 ）

ISSN： 0003-9861

年卷期： 2020 年 680 卷

页码：

收录情况： SCI

摘要： Inflammatory bowel disease (IBD) is a chronic inflammatory condition with high incidence. Syringin exhibits multiple pharmacological properties, including anti-inflammatory effects. However, the effect of syringin on inflammation of IBD is still unclear. Here, the dextran sulfate sodium (DSS)-induced colitis model was established in vivo. Rat intestinal epithelium IEC6 cells were treated with lipopolysaccharide (LPS) in vitro. Syringin inhibited DSS or LPS-induced overproduction of proinflammatory cytokines (IL-1 beta, IL-6, TNF-alpha) and proinflammatory substances (iNOS, COX-2). Moreover, syringin inactivated the proinflammatory NF-kappa B p65 pathway by decreasing I kappa B alpha phosphorylation at Ser 32. The activation of antioxidant Nrf2 signaling pathway was promoted by syringin. Additionally, LPS-induced inflammation in IEC6 cells was also suppressed by NF-kappa B inhibitor PDTC and Nrf2 activator RTA408. The anti-inflammatory effects of syringin were comparable to these two reagents. Taken together, our results suggest that syringin shows protective effects on intestinal inflammation through inhibiting NF-kappa B, while activating Nrf2 signaling pathway in colitis.

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