Protective effect of curcumin on ochratoxin A-induced liver oxidative injury in duck is mediated by modulating lipid metabolism and the intestinal microbiota
文献类型： 外文期刊
第一作者： Zhai, S. S.
作者： Zhai, S. S.;Zhu, Y. W.;Ye, H.;Wang, W. C.;Yang, L.;Ruan, D.;Li, M. C.
作者机构：
关键词： curcumin; ochratoxin A; duck; liver oxidative injury; intestinal microbiota
期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）
ISSN：
年卷期： 2020 年 99 卷 2 期
页码：
收录情况： SCI
摘要： Curcumin has antioxidant functions, regulates the intestinal microbial composition, and alleviates mycotoxin toxicity. The present study aimed to explore whether curcumin could alleviate ochratoxin A (OTA)-induced liver injury via the intestinal microbiota. A total of 720 mixed-sex 1-day-old White Pekin ducklings were randomly assigned into 4 groups: CON (control group, without OTA), OTA (fed a diet with 2 mg/kg OTA), CUR (ducks fed a diet with 400 mg/kg curcumin), and OTA + CUR (2 mg/kg OTA plus 400 mg/kg curcumin). Each treatment consisted of 6 replicates and 30 ducklings per replicate. Treatment lasted for 21 D. Results were analyzed by a two-tailed Student t test between 2 groups. Our results demonstrated that OTA treatment had the highest serum low-density lipoprotein (LDL) level among 4 groups. Compared with OTA group, OTA + CUR decreased serum LDL level (P < 0.05). OTA decreased liver catalase (CAT) activity in ducks (P < 0.05), while addition of curcumin in OTA group increased liver CAT activity (P < 0.05). 16S ribosomal RNA sequencing suggested that curcumin increased the richness indices (ACE index) and diversity indices (Simpson index) compared with OTA group (P < 0.05) and recovered the OTA-induced alterations in composition of the intestinal microbiota. Curcumin supplementation relieved the decreased abundance of butyric acid producing bacteria, including blautia, butyricicoccus, and butyricimonas, induced by OTA (P < 0.05). OTA also significantly influenced the metabolism of the intestinal microbiota, such as tryptophan metabolism and glyceropholipid metabolism. Curcumin could alleviate the upregulation of oxidative stress pathways induced by OTA. OTA treatment also increased SREBP-1c expression (P < 0.05). The curcumin group had the lowest expression of FAS and PPARG mRNA (P < 0.05) and the highest expression of NRF2 and HMOX1 mRNA. These results indicated that curcumin could alleviate OTA-induced oxidative injury and lipid metabolism disruption by modulating the cecum microbiota.
分类号：
- 相关文献
作者其他论文 更多>>
-
First Report of Rhizopus stolonifer Causing Flower Rot of Yellow Passion Fruit (Passiflora edulis f. flavicarpa) in China
作者：Sun, J. M.;Zhang, J. Z.;Sun, J. M.;Chen, G.;Yang, L.;Chen, G.;Huang, Y. C.;Yang, L.;Qin, J. F.
关键词：flower rot; passion fruit; pathogen identification; Rhizopus stolonifer
-
Dietary isoleucine supplementation enhances growth performance, modulates the expression of genes related to amino acid transporters and protein metabolism, and gut microbiota in yellow-feathered chickens
作者：Ruan, D.;Fan, Q. L.;Zhang, S.;Lin, X. J.;Zheng, C. T.;Jiang, Z. Y.;Jiang, S. Q.;EI-Senousey, H. K.;Fouadt, A. M.;Yan, S. J.;Yan, S. J.
关键词：isoleucine; yellow -feathered chickens; amino acid transporters; protein metabolism; gut microbiota
-
PRODUCTION OF MICROBIOLOGICAL PROTEIN FEED FROM SWEET POTATO (Ipomoea batatas L. Lam) RESIDUE BY CO-CULTIVATION SACCHAROMYCES CEREVISIAE AND CANDIDA UTILIS
作者：Jin, Y. L.;Shen, W. L.;Fang, Y.;Yi, Z. L.;Yang, L.;Zhao, H.;Ding, F.;Jin, Y. L.
关键词：Sweet potato starch residue; Protein Feed; Saccharomyces cerevisiae; Candida utilis; Resource regeneration
-
Dietary vitamin D3 requirement of magang goslings from 1-21 days of age
作者：Wang, H.;Wang, X. Y.;Zhan, Y. C.;Wang, W. C.;Yang, L.;Zhu, Y. W.;Peng, B.;Zhang, H. Q.
关键词：Vitamin D-3 requirement; Geese; Calcium-phosphorus metabolism; Tibia development
-
Passion fruit peel and its zymolyte enhance gut function in Sanhuang broilers by improving antioxidation and short-chain fatty acids and decreasing inflammatory cytokines
作者：Ju, Y.;Luo, H. L.;Huang, Y. C.;Chen, G.;Gui, J.;Yang, L.;Huang, L. L.;Liu, Z. L.;Lin, X. Z.;Huang, X. Y.
关键词：Sanhuang broiler; passion fruit peel; enzymolytic passion fruit peel; antioxidant status; anti-inflammatory
-
Comparative effects of inorganic and organic manganese supplementation on productive performance, egg quality, tibial characteristics, serum biochemical indices, and fecal Mn excretion of laying ducks
作者：Zhang, Y. N.;Wang, S.;Huang, X. B.;Li, K. C.;Ruan, D.;Xia, W. G.;Wang, S. L.;Chen, W.;Zheng, C. T.
关键词：Manganese; Productive performance; Egg quality; Tibial characteristics; Fecal Mn excretion; Laying duck
-
Change of zinc mobilization and gene expression of key zinc transport proteins between the yolk sac membrane and liver of duck embryonic developing
作者：Bai, S. P.;Gao, W.;Yuan, T.;He, L. J.;Huang, L.;Wang, W. C.;Yang, L.;Zhu, Y. W.;Bai, S. P.;Ma, X. Y.;Wei, S.;Liu, C.
关键词：zinc mobilization; developmental change; zinc transport protein; duck embryo
