Novel copy number variations of the CHRM3 gene associated with gene expression and growth traits in Chinese Datong yak (Bos grunniens)

文献类型： 外文期刊

第一作者： Goshu, Habtamu Abera

作者： Goshu, Habtamu Abera;Wu Xiaoyun;Min Chu;Bao Pengjia;Ding Xue Zhi;Yan Ping;Goshu, Habtamu Abera

作者机构：

关键词： Ages; body weight; function; transcription

期刊名称：JOURNAL OF APPLIED ANIMAL RESEARCH （ 影响因子：1.63； 五年影响因子：1.727 ）

ISSN： 0971-2119

年卷期： 2020 年 48 卷 1 期

页码：

收录情况： SCI

摘要： A previous study using next-generation sequencing illustrated and confirmed that the cholinergic receptor muscarinic 3 (CHRM3) gene resides within CNVRs of yak populations that overlap with quantitative trait loci (QTL) relating to meat quality and growth, and plays a prominent role in smooth muscle contraction. This study was conducted to determine the distribution of the CNVs of the CHRM3 gene in five Chinese domestic yak breeds and to investigate the influences of the CHRM3 gene on the gene expression and growth traits of the Datong yak. The data were analyzed by ANOVA using SPSS software. Our results revealed that a gain CNV type in the CHRM3 gene is more highly associated (P < 0.05) with various growth traits in six-month-old and five-year-old Datong yaks. The gain CNV type of the CHRM3 gene more frequently occurred than loss and normal types in all yak breeds. Nevertheless, the CHRM3 gene copy number had a highly significant (P < 0.0012) and moderately negative correlation with the mRNA transcription levels were determined in the skeletal muscle of Chinese Datong yaks. Therefore, we concluded that this study provided inclusive information on the application of CNVs of the CHRM3 in growth traits and its possible function.

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