Alginate-based microcapsules loaded with Brazilian green propolis decrease reactive oxygen species production, reduce inflammatory cytokines, and mitigate intestinal inflammation

文献类型： 外文期刊

第一作者： Franchin, Marcelo

作者： Franchin, Marcelo;Bennett, Jason;Granato, Daniel;Franchin, Marcelo;Gonsalves, Eduardo Da Campo Junqueira;Saliba, Ana Sofia Martelli Chaib;Spada, Fernanda Papa;de Alencar, Severino Matias;Ramos, Anderson dos Santos;dos Santos, Daniela Coelho;Cunha, Thiago Mattar;Bueno-Silva, Bruno;Xu, Yandong;Wang, Kai;de Alencar, Severino Matias

作者机构：

关键词： Propolis; Microcapsules; Inflammation; Cytokines; Antioxidant; Galleria mellonella; Macrophage; Alginate

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 310 卷

页码：

收录情况： SCI

摘要： Ulcerative colitis causes intestinal inflammation, with treatments often limited in efficacy and safety. New technologies enable the controlled release of bioactive compounds, and Brazilian green propolis could benefit in managing inflammation. This study proposed developing alginate-based microcapsules loaded with ethanolic extract of green propolis (EEGP-MC), evaluating their effects on inflammatory cytokines, reactive oxygen species, and experimental colitis. The results demonstrated that the EEGP-MC reached peak release of phenolic compounds in the intestinal phase (IP) at 4 h (76.9 %) and 6 h (75.0 %). Similarly, Artepillin C peaked at 22.3 +/- 1.2 mg/g at 4 h and 22.5 +/- 1.1 mg/g at 6 h in the IP. In THP-1 cell cultures, pretreatment with EEGP-MC (1000 mu g/ mL) and IP (300 and 1000 mu g/mL) reduced TNF-alpha and IL-6 levels and ROS production. Additionally, oral administration of EEGP-MC at 300 mg/kg demonstrated superior protective activity in the colonic mucosa, reducing lesions by 86.1 % compared to 54.9 % with EEGP alone. Finally, the treatment with EEGP-MC suppressed TNF-alpha, IL-6, and IL-1(3 cytokines in the intestinal tissue. No toxicity was observed for the EEGP-MC. These findings highlight EEGP-MC as an innovative technology with promising applications for managing chronic inflammation in the food and pharmaceutical industries.

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