Preparation and evaluation of danofloxacin mesylate microspheres and its pharmacokinetics in pigs

文献类型： 外文期刊

第一作者： Wang, Chunmei

作者： Wang, Chunmei;Chen, Cuilan;Lin, Heng;Li, Jing;Shen, Hongchun;Yi, Weixue;Qi, Yuanhua;Wu, Haigang;Cao, Jiyue;Ai, Diyun

作者机构：

关键词： swine;pharmacokinetics;drug evaluation;particle size;crosslinking;quinolones;emulsions;in vitro studies;intramuscular injection;lungs;half life

期刊名称：VETERINARY RESEARCH COMMUNICATIONS （ 影响因子：2.459； 五年影响因子：2.352 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Danofloxacin mesylate gelatin microspheres (DFM-GMS) were prepared by an emulsion chemical crosslinking technique. Distribution of particle size, morphologic characteristics, drug content, and drug stability were evaluated. In-vitro study showed that the release of danofloxacin mesylate (DFM) from microspheres was much slower than from the raw material (DFM) in the release medium. Pharmacokinetic characteristics were evaluated following intramuscular injection of DFM-GMS or DFM in pigs at dosage of 2.5 mg/kg body weight. Elimination half-life (t/o) of the drug was 24.32 h for DFM-GMS, and 6.61 h for DFM (P<0.01). Overall, DFM-GMS could be applied as a long-acting and lung targeting dosage form of DFM for clinical application.

分类号： S85

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