Pectin pentasaccharide from hawthorn (Crataegus pinnatifida Bunge. Var. major) ameliorates disorders of cholesterol metabolism in high-fat diet fed mice
文献类型： 外文期刊
第一作者： Zhu, Rugang
作者： Zhu, Rugang;Li, Tuoping;Dong, Yinping;Liu, Yonghui;Zhao, Zhongsheng;Jia, Youfeng;Li, Suhong;Chen, Gang
作者机构：
关键词： Hawthorn; SREBP-2; Low density lipoprotein receptor; Enzyme activity; Gene expression
期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：7.425； 五年影响因子：7.716 ）
ISSN： 0963-9969
年卷期： 2013 年 54 卷 1 期
页码：
收录情况： SCI
摘要： The effects of haw pectin pentasaccharide (HPPS) on hypercholesterolemia were investigated in high-fat fed mice. HPPS significantly decreased the levels of serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c), and hepatic TC. It also significantly decreased the activities and gene expressions of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) and acyl-coenzyme A: cholesterol acyl-transferase (ACAT) in the liver. While, the serum high density lipoprotein cholesterol (HDL-c), fecal bile acids, and the activity and gene expressions of cholesterol 7 alpha-hydroxylase (CYP7A1) were significantly increased by HPPS administration. Moreover, HPPS tended to increase the fecal TC level and to down-regulate the expressions of sterol regulatory element-binding protein 2 (SREBP-2) and LDL receptor in the liver, but no statistical significance was detected. The results revealed that HPPS have great potential in the development of functional food to improve cholesterol metabolism. (C) 2013 Elsevier Ltd. All rights reserved.
分类号：
- 相关文献
作者其他论文 更多>>
-
Effects of plant source selection and chemi-mechanical treatment on the fiber microstructures and mechanical behaviors of nanocellulose films
作者：Qian, Yangyang;Qian, Yangyang;Wang, Chunyu;Liu, Yijun;Wei, Yuan;Chen, Gang;Shi, Bingfei;Zhang, Jianqiang;Liu, Yijun
关键词：
-
Trace phospholipid and fatty acid differences between dairy and plant-based milk products by 1 H and 31 P NMR spectroscopy combined with multivariate statistical analysis
作者：Wang, Tongtong;Tan, Sijia;Li, Liang;Jiang, Bin;Wang, Dan;Liu, Qingyi;Chen, Gang
关键词：Dairy cream; Butter; Plant-based cream; Margarine; Multivariate statistical analysis
-
Sustainable, biodegradable, and recyclable bioplastics derived from renewable carboxymethyl cellulose and waste walnut shell
作者：Qian, Yangyang;Qin, Changpei;Zhang, Jianqiang;Shi, Bingfei;Wei, Yuan;Niu, Jingchao;Kang, Shimin;Wang, Chunyu;Chen, Gang;Qian, Yangyang;Wei, Yuan;Liu, Yijun
关键词：Carboxymethyl cellulose; Waste walnut shell; One-pot casting; Bioplastics; UV-blocking
-
Optimization of Phenolic Compound Extraction from Pineapple Leaf Fiber: Stability Enhancement and Application in Mango Preservation
作者：Liu, Yijun;Ma, Huifang;Wang, Yuhan;Liu, Yijun;Chen, Gang;Li, Qiangyou;Shi, Mingyang
关键词：pineapple leaf fiber; phenolic compounds; extract; preservation
-
Advances in conventional and innovative anti-allergic agents for managing food allergies: from mechanisms to challenges
作者：Zhu, Yuying;Zhou, Enning;Wu, Liming;Li, Qiangqiang;Chen, Gang;Kamal-Eldin, Afaf
关键词：food allergy; anti-allergic agents; natural bioactive ingredients; nano/micro-carriers; nanoparticles
-
Bioactive nanocomposite hydrogel with synergistic antibacterial and cytoprotective functions: Multi-target keratinocyte modulation for infected wound regeneration
作者：Zhou, Enning;Zhu, Yuying;Zhao, Liuwei;Wang, Miao;Wu, Liming;Li, Qiangqiang;Chen, Gang;Liu, Dongyuan
关键词：Bacterial infected wound healing; Carbon dots; Multifunctional hydrogels; Royal jelly and honey; Bioactive nanomaterials
-
Multifunctional carbon dots with full-band UV-to-HEBL shielding and antibacterial properties in polyvinyl alcohol film for enhancing food preservation
作者：Duan, Hong;Zhang, Manli;Zheng, Lingyan;Sun, Baoguo;Chen, Gang;Deng, Yuming;Deng, Yuming;Wang, Tongtong
关键词：Ferulate ester; Carbon dots; UV light blocking; Anti-bacterial; Food packaging
