Pectin pentasaccharide from hawthorn (Crataegus pinnatifida Bunge. Var. major) ameliorates disorders of cholesterol metabolism in high-fat diet fed mice

文献类型： 外文期刊

第一作者： Zhu, Rugang

作者： Zhu, Rugang;Li, Tuoping;Dong, Yinping;Liu, Yonghui;Zhao, Zhongsheng;Jia, Youfeng;Li, Suhong;Chen, Gang

作者机构：

关键词： Hawthorn; SREBP-2; Low density lipoprotein receptor; Enzyme activity; Gene expression

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：7.425； 五年影响因子：7.716 ）

ISSN： 0963-9969

年卷期： 2013 年 54 卷 1 期

页码：

收录情况： SCI

摘要： The effects of haw pectin pentasaccharide (HPPS) on hypercholesterolemia were investigated in high-fat fed mice. HPPS significantly decreased the levels of serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c), and hepatic TC. It also significantly decreased the activities and gene expressions of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) and acyl-coenzyme A: cholesterol acyl-transferase (ACAT) in the liver. While, the serum high density lipoprotein cholesterol (HDL-c), fecal bile acids, and the activity and gene expressions of cholesterol 7 alpha-hydroxylase (CYP7A1) were significantly increased by HPPS administration. Moreover, HPPS tended to increase the fecal TC level and to down-regulate the expressions of sterol regulatory element-binding protein 2 (SREBP-2) and LDL receptor in the liver, but no statistical significance was detected. The results revealed that HPPS have great potential in the development of functional food to improve cholesterol metabolism. (C) 2013 Elsevier Ltd. All rights reserved.

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