文献类型： 外文期刊
第一作者： Ji, Kai-Long
作者： Ji, Kai-Long;GongPan, Pian-Chou;Sun, Peng;Lu, Jian-Mei;Tang, Yan-Qing;Guo, Zheng-Yang;Li, Ting;Dai, Meng-Yuan
作者机构：
关键词： Glycosmis lucida; geranylated sulfonyl amides; glylucidamides; Th17 differentiation; ROR gamma t
期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.9； 五年影响因子：2.8 ）
ISSN： 1612-1872
年卷期： 2023 年 20 卷 6 期
页码：
收录情况： SCI
摘要： Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1-10), including two previously unreported geranylated sulfurcontaining amides (1 and 2) and eight known ones (3-10). Structural characterization was carried out using comprehensive spectroscopic methods including NMR, MS and CD. The inhibitory effects of all isolates on Th17 differentiation were evaluated, of which compounds 1 and 6 significantly inhibited Th17 differentiation with IC50 values of 0.36 and 1.30 mu M, respectively, while both 1 and 6 failed to bind to retinoic acid-related orphan receptor gamma t (ROR gamma t), suggesting that their inhibition of Th17 differentiation is independent of ROR gamma t.
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