Comparison of the immunological activities of arabinoxylans from wheat bran with alkali and xylanase-aided extraction

文献类型： 外文期刊

第一作者： Guo, Yan

作者： Guo, Yan;Cao, Li;Guo, Yan;Cao, Li;Zhou, Sumei;Wang, Qiang;Liu, Xiuzhen;Peng, Daiyin

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关键词： Wheat bran arabinoxylan;Alkaline extraction;Enzyme extraction;Immunomodulators

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

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收录情况： SCI

摘要： Differences in immunoregulatory activities of arabinoxylans (AXs) from wheat bran extracted by alkaline-and enzyme-based methods are unknown. We extracted AX from wheat bran by the 2 procedures. Chemical analysis revealed that alkaline-extracted AX (AX_A) contained a lower amount of protein (4.10%) than enzyme-extracted AX (AX_E, 9.85%) and no ferulic acid (as compared with 43.5mg/100g in AX_E). AX_A consisted of a highly substituted population with a ratio of arabinose to xylose of 0.83 (AX_e: 0.56), meanwhile the weight-average molecular weight of AX_A (3.517 x10~5 Da) was about 10 times that of AX_e (3.252 x 10~4 Da). Both AX_A and AX_E had potent stimulating effects on innate and acquired immune responses on oral administration in female BALB/c mice. AX_E showed higher macrophage phagocytosis and delayed hypersensitivity reaction than did AX_A, with no significant differences in enhancing lymphocyte proliferation. Whether extracted by alkaline- or enzyme-aided methods, the obtained AXs could be explored as potent natural immunomodulators.

分类号： O629

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