Caffeic acid phenethyl ester: an effective antiviral agent against porcine reproductive and Respiratory Syndrome Virus

文献类型： 外文期刊

第一作者： Cui, Zhanding

作者： Cui, Zhanding;Zhang, Jing;Wang, Jinlong;Liu, Jinlong;Sun, Pu;Li, Jiaoyang;Li, Guoxiu;Sun, Ying;Ying, Juanbin;Li, Kun;Zhao, Zhixun;Yuan, Hong;Bai, Xingwen;Ma, Xueqing;Li, Pinghua;Fu, Yuanfang;Bao, Huifang;Li, Dong;Zhang, Qiang;Liu, Zaixin;Cao, Yimei;Lu, Zengjun;Wang, Jinlong;Sun, Ying

作者机构：

关键词： Porcine reproductive and respiratory syndrome; Caffeic acid phenethyl ester; Antiviral agent; Swine viral infections; In vivo

期刊名称：ANTIVIRAL RESEARCH （ 影响因子：7.6； 五年影响因子：5.8 ）

ISSN： 0166-3542

年卷期： 2024 年 225 卷

页码：

收录情况： SCI

摘要： Porcine Reproductive and Respiratory Syndrome (PRRS) presents a formidable viral challenge in swine husbandry. Confronting the constraints of existing veterinary pharmaceuticals and vaccines, this investigation centers on Caffeic Acid Phenethyl Ester (CAPE) as a prospective clinical suppressant for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study adopts an integrated methodology to evaluate CAPE's antiviral attributes. This encompasses a dual-phase analysis of CAPE's interaction with PRRSV, both in vitro and in vivo, and an examination of its influence on viral replication. Varied dosages of CAPE were subjected to empirical testing in animal models to quantify its efficacy in combating PRRSV infections. The findings reveal a pronounced antiviral potency, notably in prophylactic scenarios. As a predominant component of propolis, CAPE stands out as a promising candidate for clinical suppression, showing exceptional effectiveness in pre-exposure prophylaxis regimes. This highlights the potential of CAPE in spearheading cutting-edge strategies for the management of future PRRSV outbreaks.

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