Whole-Genome Sequencing for Identifying Candidate Genes Related to the Special Phenotypes of the Taihu Dianzi Pigeon

文献类型： 外文期刊

第一作者： Zhang, Rui

作者： Zhang, Rui;Mu, Chunyu;Chang, Lingling;Shen, Xinyue;Bu, Zhu;Fu, Shengyong;Tang, Qingping;Yang, Mingjun;Liu, Peiyao;Yang, Xiaoming

作者机构：

关键词： whole-genome sequencing; piebalding; crest; polydactyly

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 7 期

页码：

收录情况： SCI

摘要： Simple Summary Pigeons are highly diverse and exhibit a variety of external features, such as a special piebald pattern, crest, and polydactyly. However, the mechanism underlying the formation of these special phenotypes has not been elucidated. We aimed to study the candidate genes associated with the special piebald, crest, and polydactyly traits in the Taihu Dianzi pigeon. Some candidate genes were identified by a selective sweep and GWAS. This result may be important for understanding each trait, which could establish a foundation for the development and utilization of local pigeon resources in China.Abstract The Taihu Dianzi pigeon is a breed native to China, and its special piebalding, crest, and polydactyly phenotypes are the result of artificial and natural selection. Here, we analyzed the genetic differences among three kinds of pigeons with different phenotypes at the genomic level. A selective sweep was conducted based on the fixation index (FST) and nucleotide diversity (pi) ratio, and the results revealed that MC1R was related to the formation of the distinctive piebalding of the Taihu Dianzi pigeon. Combined with the results of genome-wide association studies, we identified candidate genes associated with the crest (SMYD and STOX2) and polydactyly (SLC52A3 and ANGPT4). The candidate genes identified in this study and their variants may be useful for understanding the genetic mechanism underlying the special phenotypes of the Taihu Dianzi pigeon. This study provides new insights into the genetic factors that may influence the formation of the special piebalding, crest, and polydactyly characteristics in pigeons.

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