Metagenomic survey of viral diversity obtained from feces of piglets with diarrhea

文献类型： 外文期刊

第一作者： Qian, Lingling

作者： Qian, Lingling;Lu, Juan;Wang, Xiaochun;Yang, Shixing;Ji, Likai;Shen, Quan;Zhang, Wen;Zhuang, Zi;Wang, Huiying;Shan, Tongling

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关键词： Diarrhea piglets; Feces; Metagenomic; Viral communities; Virus genome

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

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年卷期： 2024 年 10 卷 4 期

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收录情况： SCI

摘要： Pigs are natural host to various zoonotic pathogens including viruses. In this study, we analyzed the viral communities in the feces of 89 piglets with diarrhea under one month old which were collected from six farms in Jiangsu Province of the Eastern China, using the unbiased virus metagenomic method. A total of 89 libraries were constructed, and 46937894 unique sequence reads were generated by Illumina sequencing. Overall, the family Picornaviridae accounted for the majority of the total reads of putative mammalian viruses. Ten novel virus genomes from different family members were discovered, including Parvoviridae (n = 2), Picobirnaviridae (n = 4) and CRESS DNA viruses (n = 4). A large number of phages were identified, which mainly belonged to the order Caudovirales and the family Microviridae. Moreover, some identified viruses were closely related to viruses found in non-porcine hosts, highlighting the potential for cross -species virus dissemination. This study increased our understanding of the fecal virus communities of diarrhea piglets and provided valuable information for virus monitoring and preventing.

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