Structural characterization and hypolipidemic activity of Gracilaria lemaneiformis polysaccharide and its degradation products

文献类型： 外文期刊

第一作者： Long, Xiaoshan

作者： Long, Xiaoshan;Liu, Shucheng;Long, Xiaoshan;Hu, Xiao;Xiang, Huan;Chen, Shengjun;Li, Laihao;Qi, Bo;Li, Chunsheng;Yang, Xianqing;Hu, Xiao;Yang, Xianqing;Hu, Xiao;Liu, Shucheng;Yang, Xianqing

作者机构：

关键词： G. lemaneiformis; Polysaccharide; Structural characterization; Hypolipidemic activity; Pancreatic lipase; Cholesterol esterase

期刊名称：FOOD CHEMISTRY-X （ 影响因子：6.443； 五年影响因子：6.443 ）

ISSN： 2590-1575

年卷期： 2022 年 14 卷

页码：

收录情况： SCI

摘要： This research aimed to analyze structural characterization and hypolipidemic activity in vitro of G. lemaneiformis polysaccharide (GLP) and its degradation products. The results presented that the content of galacturonic acid declined and glucuronic acid level enhanced, average particle size decreased from 99.9 mu m to 25.7 mu m, and color brightness of polysaccharide strengthened after degraded by H2O2-Vc. There was no significant change in thermal stability of polysaccharide before and after degradation. It was observed in AFM analysis, polysaccharide changed to smaller, delicacy and dispersion after degradation. As seen in FT-IR, H2O2-Vc degradation never change the structure of polysaccharide. Polysaccharide and its degradation products showed a significant inhi-bition effect on pancreatic lipase and cholesterol esterase in a dose-dependent manner, which presented the mixed type of competitive and non-competitive for pancreatic lipase, and non-competitive for cholesterol esterase, respectively. The fluorescence quenching type was static on pancreatic lipase and dynamic on cholesterol esterase.

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