A detoxification pathway initiated by a nuclear receptor TcHR96h in Tetranychus cinnabarinus (Boisduval)

文献类型： 外文期刊

第一作者： Wen, Xiang

作者： Wen, Xiang;Feng, Kaiyang;Wei, Peng;He, Lin;Wen, Xiang;Feng, Kaiyang;Wei, Peng;He, Lin;Wen, Xiang;Feng, Kaiyang;Wei, Peng;He, Lin;Qin, Juan;Yuchi, Zhiguang;Cao, Peng;Zhang, Youjun

作者机构：

期刊名称：PLOS GENETICS （ 影响因子：4.5； 五年影响因子：5.5 ）

ISSN： 1553-7404

年卷期： 2023 年 19 卷 9 期

页码：

收录情况： SCI

摘要： Understanding the mechanism of detoxification initiation in arthropods after pesticide exposure is crucial. Although the identity of transcription factors that induce and regulate the expression of detoxification genes in response to pesticides is beginning to emerge, whether transcription factors directly interact with xenobiotics is unclear. The findings of this study revealed that a nuclear hormone receptor, Tetranychus cinnabarinus hormone receptor (HR) TcHR96h, regulates the overexpression of the detoxification gene TcGSTm02, which is involved in cyflumetofen resistance. The nuclear translocation of TcHR96h increased after cyflumetofen exposure, suggesting direct binding with cyflumetofen. The direct binding of TcHR96h and cyflumetofen was supported by several independent proteomic assays that quantify interactions with small molecules. Together, this study proposes a model for the initiation of xenobiotic detoxification in a polyphagous agricultural pest. These insights not only provide a better understanding of the mechanisms of xenobiotic detoxification and metabolism in arthropods, but also are crucial in understanding adaptation in polyphagous herbivores.

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