ASFV subunit vaccines: Strategies and prospects for future development

文献类型： 外文期刊

第一作者： Zhang, Yuchen

作者： Zhang, Yuchen;Mei, Xiuzhen;Xie, Xing;Zhang, Zhenzhen;Feng, Zhixin;Zhang, Yuchen;Mei, Xiuzhen;Wang, Hui;Xie, Xing;Zhang, Zhenzhen;Feng, Zhixin;Zhang, Yuchen;Mei, Xiuzhen;Wang, Hui;Xie, Xing;Zhang, Zhenzhen;Feng, Zhixin;Zhang, Chao;Wang, Hui

作者机构：

关键词： African swine fever; CD8+T cells; Adaptive immunity; Neutralizing antibodies; Subunit vaccines; Viral vectors; DNA vaccines; Protein-based vaccines

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.5； 五年影响因子：3.6 ）

ISSN： 0882-4010

年卷期： 2024 年 197 卷

页码：

收录情况： SCI

摘要： African Swine Fever (ASF) is an acute, highly contagious, and lethal disease caused by the African Swine Fever Virus (ASFV), posing a severe threat to the global pig farming industry. Although live vaccines are currently available, preventing and controlling ASF remains a considerable challenge. Several factors have impeded vaccine development, including the complexity of ASFV particles and the suppressive effects of its gene-encoded proteins on the host's immune system. This article delves into the immunological responses elicited by ASFV, encompassing both innate and adaptive immunity, and examines how ASFV evades host immune defenses. Special attention is given to the current progress in the development of ASFV subunit vaccines, including proteinbased vaccines, DNA vaccines, and viral vector vaccines. The advantages, challenges, and future directions of different vaccine types are discussed, offering new perspectives and insights for the future of ASFV vaccine development.

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