Nematicidal glycosylated resorcylic acid lactones from the fungus Pochonia chlamydosporia PC-170 and their key biosynthetic genes

文献类型： 外文期刊

第一作者： Li, Zeyu

作者： Li, Zeyu;Zhang, Wenwen;Khan, Raja Asad Ali;Ling, Jian;Zhao, Jianlong;Yang, Yuhong;Mao, Zhenchuan;Xie, Bingyan;Li, Yan;Li, Zeyu;Zhou, Ligang;Luo, Ning

作者机构：

关键词： Pochonia chlamydosporia; RALs; nematicidal activity; Meloidogyne incognita; biosynthetic gene

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

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年卷期： 2024 年 15 卷

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收录情况： SCI

摘要： Chemical study of the nematicidal biocontrol fungus Pochonia chlamydosporia PC-170 led to discovery of six resorcylic acid lactones (RALs), including three nematicidal glycosylated RALs, monocillin VI glycoside (1), colletogloeolactone A (2) and monocillin II glycoside (3), and three antibacterial non-glycosylated RALs, monocillin VI (4), monocillin IV (5) and monocillin II (6). The planar structure of the new compound monocillin VI glycoside (1) was elucidated using HRESIMS and NMR data, and its monosaccharide configuration was further determined through sugar hydrolysis experiment and GC-MS analysis method. Furthermore, their two biosynthetic-related PKS genes, pchE and pchI, were identified through the gene knockout experiment. The glycosylated RALs 1-3 exhibited nematicidal activity against Meloidogyne incognita, with LC50 values of 94, 152 and 64 mu g/mL, respectively, and thus had great potential in the development of new nematicidal natural products to control M. incognita in the future.

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