PEtN-Modified O-Antigen Enhances Shigella Pathogenesis by Promoting Epithelial Cell Invasion and Inhibiting Complement Binding

文献类型： 外文期刊

第一作者： Zheng, Ruicheng

作者： Zheng, Ruicheng;Qiao, Lu;An, Yina;Ling, Zhuoren;Shen, Jianzhong;Dong, Yanjun;Wang, Yang;Li, Wan;Yin, Wenjuan;Song, Shikai;Bai, Li;Yang, Hui

作者机构：

关键词： Shigella flexneri; polysaccharide; O-antigen; virulence; complement

期刊名称：ACS INFECTIOUS DISEASES （ 影响因子：5.3； 五年影响因子：5.1 ）

ISSN： 2373-8227

年卷期： 2024 年 10 卷 2 期

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收录情况： SCI

摘要： Shigellosis poses an ongoing global public health threat. The presence and length of the O-antigen in lipopolysaccharide play critical roles in Shigella pathogenesis. The plasmid-mediated opt gene encodes a phosphoethanolamine (PEtN) transferase that catalyzes the addition of PEtN to the O-antigen of Shigella flexneri serotype X and Y strains, converting them into serotype Xv and Yv strains, respectively. Since 2002, these modified strains have become prevalent in China. Here we demonstrate that PEtN-mediated O-antigen modification in S. flexneri increase the severity of corneal infection in guinea pigs without any adaptive cost. This heightened virulence is associated with epithelial cell adhesion and invasion, as well as an enhanced inflammatory response of macrophage. Notably, PEtN addition allow S. flexneri to attenuate the binding of complement C3 and better resist phagocytosis, potentially contributing to the retention of S. flexneri in the host environment.

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