文献类型： 外文期刊
第一作者： Jiao, Fengyuan
作者： Jiao, Fengyuan;Zhou, Gengxu;Meng, Chi;Wang, Lingjie;Wu, Shengping;Li, Jixiang;Cao, Liting;Luo, Yichen;Jiao, Hanwei;Zhao, Yu;Zhou, Bo
作者机构：
关键词： HE; HEV; ORF3
期刊名称：MICROORGANISMS （ 影响因子：4.1； 五年影响因子：4.5 ）
ISSN：
年卷期： 2024 年 12 卷 7 期
页码：
收录情况： SCI
摘要： Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the world and is a significant public health problem. The pathogen, HEV, has three Open Reading Frames (ORFs) ORF1, ORF2, and ORF3, each of which has a different function. Most of the current research is focused on ORF1 and ORF2, while the research on ORF3 is still relatively small. To provide more ideas for the study of HEV pathogenesis and the prevention and treatment of HE, this paper reviews the effects of ORF3 on the ERK pathway, growth factors, immune response, and virus release.
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