Enzymatic hydrolysis of cassava leaf proteins unlocks antioxidant and therapeutic peptides: Alcalase-derived bioactives target oxidative stress pathways

文献类型： 外文期刊

第一作者： Zhang, Jinquan

作者： Zhang, Jinquan;Fang, Yusi;Song, Yong;Zhang, Jinquan;Zhang, Zuoda;Yu, Houmei;Lin, Liming;Wang, Qinfei;Zhang, Zhenwen;Yu, Houmei;Lin, Liming;Wang, Qinfei;Zhang, Zhenwen;Yu, Houmei;Lin, Liming;Wang, Qinfei;Zhang, Zhenwen;Song, Yong

作者机构：

关键词： Cassava leaves; Bioactive peptides; Network pharmacology; Molecular docking

期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）

ISSN： 0308-8146

年卷期： 2025 年 491 卷

页码：

收录情况： SCI

摘要： Cassava leaves, often discarded as agricultural byproduct, are a nutrient-dense yet underutilized protein source, containing 38 % proteins by dried weight. This study investigates the potential of cassava leaf proteins as a sustainable alternative to conventional protein sources through enzymatic hydrolysis. Bioactive peptides extracted during hydrolysis significantly improve the protein's nutritional profile and exhibited diverse biological activities. Analysis revealed a notable increase in essential amino acids, comprising similar to 40 % of total amino acids. Using LC-MS/MS, 36 distinct peptide sequences were identified. Bioinformatics and network pharmacology analyses revealed that cassava leaf peptides possess antioxidant, anti-inflammatory, immunomodulatory, anticancer, and neuroprotective properties. Notably, the peptide sequences HPDGF and SEGGF exhibited strong binding affinity to key targets (AKT1, CASP3, CCND1, and IL1B), suggesting therapeutic potential for oxidative stress-related pathologies. These findings underscore the potential of cassava leaf proteins as a natural, sustainable source of bioactive peptides for health applications, notably as antioxidants.

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