Construction and application of an electrochemical sensor based on MIL-101-NH2(Fe)-derived Fe-C porous materials doped with reduced graphene oxide for baicalin detection

文献类型： 外文期刊

第一作者： Liu, Zhichao

作者： Liu, Zhichao;Cao, Xiyue;Xia, Jianfei;Wang, Zonghua;Han, Lida;Li, Xiaojing

作者机构：

关键词： Electrochemical sensor; Pyrolytic carbon; MIL-101-NH 2 (Fe); Baicalin; Physical doping

期刊名称：MICROCHEMICAL JOURNAL （ 影响因子：5.1； 五年影响因子：4.7 ）

ISSN： 0026-265X

年卷期： 2025 年 208 卷

页码：

收录情况： SCI

摘要： Baicalin (Bn), a natural flavonoid compound, possesses high pharmacological effects. Here, an electrochemical sensor has been proposed based on an MIL-101-NH2(Fe)-derived Fe porous carbon composite (Fe-C) doped with reduced graphene oxide (rGO) for detecting Bn, designated as Fe-C/rGO. Fabricated through a straightforward physical doping process, Fe-C/rGO exhibits remarkable electrochemical activity. This superiority stems primarily from two key factors. Firstly, the porous structure of Fe-C efficiently concentrates Bn, facilitating its capture and recognition. Secondly, graphene oxide, serving as a substrate for anchoring metal-organic frameworks (MOFs), boosts the electrochemical performance of the composite due to its distinctive two-dimensional structure, abundant active sites, and unparalleled stability. The synergistic interaction between Fe-C and rGO maximizes their respective advantages, leading to a significant enhancement in the sensitivity and selectivity of the electrochemical sensor. Boasting a low detection limit of 7.5 nM and a broad detection range spanning from 30 to 180 nM, this sensor holds immense potential in clinical applications and drug monitoring, offering a reliable and efficient method for Bn detection.

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