文献类型： 外文期刊
第一作者： Yu, Zhuo
作者： Yu, Zhuo;Huang, Wenbo;Shi, Liqiao;Ke, Shaoyong;Yu, Zhuo;Xu, Shengzhen
作者机构：
关键词： Benthiazole; Conjugated system; Chemosensor; G-quadruplex DNA; In vivo imaging
期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：8.455； 五年影响因子：5.935 ）
ISSN： 1001-8417
年卷期： 2022 年 33 卷 3 期
页码：
收录情况： SCI
摘要： Several probes containing benzothiazole-guided conjugated systems (BGCS) were designed and synthesized, and two molecules (BGCS5 and BGCS6) of which were discovered as selective probes targeting c-MYC Pu22 G-quadruplex DNA. The fluorescence intensity of BGCS5 and BGCS6 in the presence of c-MYC Pu22 far exceeds that of the typical G4 probe TO1. Especially, the fluorescence of BGCS6 increased almost 193-fold in the presence of c-MYC Pu22 G4 compared to that alone in aqueous buffer condition with almost no fluorescence and 10-30 folds than those in the presence of other DNAs, which will be useful tools for disease detection in mammals. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
分类号：
- 相关文献
作者其他论文 更多>>
-
The influence of traceability label trust on consumers' traceability pork purchasing behavior: Based on the moderating effect of food safety identification
作者：Liu, Zengjin;Yu, Meilian;Yu, Zhuo;Zhao, Jing;Han, Xibing;Geng, Ning;Li, Caixia
关键词：
-
A soybean cyst nematode suppresses microbial plant symbionts using a lipochitooligosaccharide-hydrolysing enzyme
作者：Chen, Wei;Wang, Di;Xiang, Wensheng;Yang, Qing;Chen, Wei;Yang, Qing;Ke, Shaoyong;Cao, Yangrong;Guo, Xiaoli
关键词：
-
Substituted pyrazole derivatives as potential fungicidal agents
作者：Huang, Daye;Liu, Fang;Wen, Shaohua;Wang, Yueying;Fang, Wei;Zhang, Zhigang;Ke, Shaoyong
关键词：Pyrazole carboxamide; Hydrazone; Plant disease; Fungicidal activity
-
Discovery of structural diversity guided steroidal thiazolidin-4-one derivatives as potential cytotoxic agents targeting CDK1
作者：Yang, Fei;Min, Yong;Li, Kui;Yang, Ziwen;Wang, Kaimei;Gong, Yan;Liu, Manli;Ke, Shaoyong;Yang, Fei;Yang, Ziwen;Liu, Changli
关键词：Steroidal thiazolidin-4-ones; Structural diversity; Antiproliferative activity; Enzyme inhibitors; Molecular docking
-
Highly efficient construction of multi-substituted aminopyrazoles derivatives via iodine-mediated three-components reaction as potential anticancer agents
作者：Gao, Zilin;Liu, Manli;Shi, Liqiao;Zhang, Zhigang;Yang, Fei;Wang, Kaimei;Ke, Shaoyong;Gao, Zilin;Chen, Yu;Cao, Xiufang;Huang, Wenbo;Yang, Fei;Cao, Xiufang;Wang, Kaimei;Ke, Shaoyong
关键词：Aminipyrazole derivatives; three-component reaction; reaction mechanism; biological application; SARs; kinase inhibitor; molecular docking
-
Discovery of Novel Carboxamide Derivatives Containing Biphenyl Pharmacophore as Potential Fungicidal Agents Used for Resistance Management
作者：Ke, Shaoyong;Gao, Zilin;Zhang, Zhigang;Liu, Fang;Wen, Shaohua;Wang, Yueying;Huang, Daye;Gao, Zilin
关键词：biphenyl derivatives; synthesis; fungicidalactivity; Botrytis cinerea; resistantstrain; mode of action
-
Novel Steroidal[17,16-d]pyrimidines Derived from Epiandrosterone and Androsterone: Synthesis, Characterization and Configuration-Activity Relationships
作者：Yang, Fei;Yang, Ziwen;Yang, Fei;Liu, Fang;Min, Yong;Shi, Liqiao;Liu, Manli;Wang, Kaimei;Ke, Shaoyong;Gong, Yan;Yang, Ziwen
关键词：epiandrosterone; androsterone; steroidal[17; 16-d]pyrimidines; synthesis; bioactivity; molecular docking; SARs
