文献类型： 外文期刊

第一作者： Mudasir, Muhammad

作者： Mudasir, Muhammad;Baig, Mirza Muhammad Ahad;Sultan, Yaqoob;Baig, Abdulsmad

作者机构：

关键词： PYL receptor; Abscisic acid; Molecular docking; Gene family; Sorghum bicolor; Phylogeny

期刊名称：GENETIC RESOURCES AND CROP EVOLUTION

ISSN： 0925-9864

年卷期： 2025 年 72 卷 4 期

页码：

收录情况： SCI

摘要： The pyrabactin resistance 1 (PYR1/PYL/RCAR) gene family serves as receptors for abscisic acid (ABA), an essential phytohormone that controls plant growth and stress responses. Further investigation is required to gain a comprehensive understanding of the evolution and role of the PYL gene family in Sorghum bicolor. In this study, the physicochemical properties, structural validation, functional motifs, evolutionary relationships among PYL gene family members, and molecular docking of the PYL proteins with ABA were extensively examined. In the sorghum genome, three distinct PYL receptors were identified: SbPYL2, SbPYL4, and SbPYL8. These receptors were modeled using the SWISS-MODEL and subsequently bound with ABA. The most stable protein-ligand complex was PYL4-ABA, which exhibited the best docking (binding energy Delta G = - 6.8 kcal/mol). This finding demonstrates the potential involvement of the PYL module in the ABA signal transduction pathway, which is crucial for the expression of stress-responsive genes. This research sheds light on the complex interactions between PYL receptors and ABA in controlling the genes in sorghum that respond to stress and offers an understanding of the abiotic stress tolerance mechanisms that can be targeted for crop improvement.

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