Flavonoid-enriched extract from Millettia speciosa Champ prevents obesity by regulating thermogenesis and lipid metabolism in high-fat diet-induced obese C57BL/6 mice

文献类型： 外文期刊

第一作者： Wang, Mao-Yuan

作者： Wang, Mao-Yuan;Wang, Qing-Long;Yang, Qing;Yan, Xiao-Xia;Tang, Huan;Li, Zhi-Ying;Li, Ying-Ying;Wang, Zhu-Nian;Wang, Mao-Yuan;Wang, Qing-Long;Yang, Qing;Yan, Xiao-Xia;Tang, Huan;Li, Zhi-Ying;Li, Ying-Ying;Wang, Zhu-Nian;Ma, Wen-Yu;Feng, Shi-Xiu;Ma, Wen-Yu;Feng, Shi-Xiu

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关键词： browning of white adipocyte; flavonoids; lipid metabolism; Millettia speciosa Champ; obesity; thermogenesis

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）

ISSN： 2048-7177

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收录情况： SCI

摘要： Millettia speciosa (M. speciosa) Champ is a medicinal and edible plant. The roots are rich in flavonoids, which possess multiple biological activities, including lipid-lowering effects. This study aimed to explore the effect of flavonoid-enriched extract from M. speciosa (FMS) on obesity. The UPLC-Q-TOF-MS analysis and chromatographic analysis were adopted to identify flavonoid compounds in FMS. Male C57BL/6.1 mice were fed with a high-fat diet for 3 months and were then treated with EMS (50 or 100 mg/kg/d) or Orlistat (10 mg kg(-1) d(-1)) for another 8 weeks. A total of 35 flavonoids were identified in the extract of M. speciosa root. FMS reduced body weight gain, liver weight gain, white adipose tissue, lipid accumulation, and blood glucose. The levels of TG, ALT, AST, and inflammatory-related adipokines (TNF-alpha and IL-6) in serum were also reduced by FMS. In addition, FMS promoted thermogenesis in brown adipose tissue and induced the activation of lipolysis, fatty acid oxidation, and oxidative phosphorylation in white adipose tissues. In summary, long-term administration of FMS could ameliorate high-fat diet-induced obesity by stimulating adipose thermogenesis and lipid metabolism.

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