Intergenerational reproductive toxicity of parental exposure to prothioconazole and its metabolite on offspring and epigenetic regulation associated with DNA methylation in zebrafish

文献类型： 外文期刊

第一作者： Tian, Sinuo

作者： Tian, Sinuo;Sun, Wei;Sun, Xiaoxuan;Yue, Yifan;Huang, Shiran;Zhou, Zhiqiang;Diao, Jinling;Yan, Sen;Zhu, Wentao;Jia, Ming;Li, Li;Yan, Sen;Zhu, Wentao

作者机构：

关键词： DNA methylation; Offspring development; Prothioconazole; Reproduction; Zebrafish

期刊名称：ENVIRONMENT INTERNATIONAL （ 影响因子：11.8； 五年影响因子：12.4 ）

ISSN： 0160-4120

年卷期： 2023 年 173 卷

页码：

收录情况： SCI

摘要： Prothioconazole (PTC) is a widely used agricultural fungicide, and its parent and metabolite prothioconazole-desthio (dPTC) have been detected in diverse environmental media. This study was aimed at investigating the gender-dependent effects on adult zebrafish reproduction and intergenerational effects on offspring development following parental exposure to PTC and dPTC. The results showed that after the adult zebrafish (F0) was exposed to 0.5 and 10 mu g/L PTC and dPTC for 21 days, the fertility and gametogenesis of female zebrafish were decreased more significantly than that of male zebrafish. After that, three fecundity tests were conducted in the exposure period to explore the development endpoints of F1 embryos/larvae without further treatment with PTC and dPTC exposure. However, PTC and dPTC exposure did lead to abnormal development of F1 embryos, including delayed hatching, shortened body length, abnormal development and significant changes in locomotor behavior. These changes were related to the abnormal expression of sex hormones and the regulation of DNA methylation in F0 fish. In a word, the results of this study showed that parental PTC and dPTC interference have sex-dependent reproductive toxicity on F0 zebrafish, which may be passed on to the next generation through epigenetic modification involving DNA methylation, resulting in alternations in growth phenotype of offspring.

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