Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

文献类型： 外文期刊

第一作者： Han, Jicheng

作者： Han, Jicheng;Zhu, Xiangyu;Gao, Zihan;Xiao, Yan;Zhang, Jinxin;Wang, Peng;Li, Yue;Jin, Ningyi;Lu, Huijun;Liu, Wenshen;Han, Jicheng;Gao, Zihan;Xiao, Yan;Zhang, Jinxin;Fang, Jinbo;Li, Yiquan;Zhu, Yilong;Li, Yue;Jin, Ningyi;Zhu, Xiangyu;Wang, Peng;Lin, Dazhuan

作者机构：

关键词： Atractyloside A; antiviral drugs; macrophage polarization; influenza virus; influenza B virus (IBV)

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN：

年卷期： 2023 年 13 卷

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收录情况： SCI

摘要： Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection.

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