Identification and exploration of the potential antiaging role of the novel antioxidant peptide DGGY derived from yak milk proteins

文献类型： 外文期刊

第一作者： Wang, Rubin

作者： Wang, Rubin;Li, Caiyan;Wang, Rubin;Zhu, Ruikai;Li, Huanhuan;Tang, Honggang;Zhao, Ke;Danzeng, Zhandu;Yang, Jinyong;Qu, Jiu;Yang, Jinyong

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关键词： antiaging yak milk; antioxidant peptide; in silico; antiaging

期刊名称：JOURNAL OF DAIRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0022-0302

年卷期： 2025 年 108 卷 6 期

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收录情况： SCI

摘要： Yak milk has substantial nutritional value yet remains underutilized for high-value applications. Because yak milk is a rich source of bioactive peptides due to its elevated protein composition, this study investigated yak milk-derived peptides with antioxidant properties and their potential antiaging mechanisms. First, 8 major yak milk proteins were hydrolyzed in silico via BIO-PEP. Compared with other enzymes, proteinase K plus subtilisin could generate more antioxidant peptides. Six potential antioxidant peptides were efficiently screened in silico; DGGY presented the strongest hydroxyl radical scavenging rate, and its antioxidant activity was further verified in Caenorhabditis elegans. Additionally, the results of network pharmacology analysis suggested an antiaging role of DGGY, which was validated in C. elegans; specifically, supplementation with DGGY (50 and 300 mu g/mL) significantly extended the life span of C. elegans by regulating the expression of related genes (including sod-3, snk-1, daf-16, daf-2, and hsp-16.2). In summary, a novel yak milk protein-derived antioxidant peptide, DGGY, was efficiently screened and found to exert potential antiaging effects. This study provides a method for the high-value utilization of yak milk and novel information for antiaging research.

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