The combination of metabolome and transcriptome clarifies the inhibition of the Alternaria toxin accumulation by methyl ferulate

文献类型： 外文期刊

第一作者： Ge, Shuai

作者： Ge, Shuai;Xie, Ying;Ding, Ke;Xu, Saiqing;Xu, Haishan;Chang, Xia;Shan, Yang;Ding, Shenghu;Ge, Shuai;Xie, Ying;Ding, Ke;Xu, Saiqing;Xu, Haishan;Chang, Xia;Li, Huan;Shan, Yang;Ding, Shenghu;Wang, Rongrong;Luo, Zisheng

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关键词： Alternaria alternata; Alternaria toxin; Methyl ferulate; Transcriptome; Metabolome

期刊名称：FOOD CHEMISTRY （ 影响因子：8.5； 五年影响因子：8.2 ）

ISSN： 0308-8146

年卷期： 2024 年 456 卷

页码：

收录情况： SCI

摘要： As one of the most typical pathogens in fruit postharvest diseases, Alternaria alternata (A. alternata) can produce Alternaria toxins (ATs) aggravating fruit decay and harming human health. In this study, ATs (tenuazonic acid, alternariol monomethyl ether, and alternariol) production was inhibited effectively by 200 and 8000 mg/L MF (methyl ferulate) in vitro and in vivo. 1-Octen-3-ol and 3-octanol were the potential iconic volatile organic compounds of ATs (R-2 > 0.99). MF induced oxidative stress, resulting in physiological and metabolic disorders, membrane lipid oxidation and cell damage. It decreased precursors and energy supply by disturbing amino acid metabolism, ABC transporters, citrate cycle, pentose and glucuronate interconversions to regulate ATs synthesis. MF down-regulated the genes related to ATs synthesis (PksJ, AaTAS1, and OmtI), transport (AaMFS1 and MFS), and pathogenicity to affect ATs production and virulence. This study provided a theoretical basis for the control of ATs production.

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