Novel compounds with promising IDO1 inhibitory activity as new cancer drug candidates: Derivatives of N,N'-diphenylurea linked with 1,2,3-triazole

文献类型： 外文期刊

第一作者： Sun, Bin

作者： Sun, Bin;Liu, Xiaofei;Sun, Xiuwei;Mao, Longfei;Shi, Weichen;Deng, Peng;Liu, Xiaofei;Sun, Xiuwei;Zhou, Yingjie;Mao, Longfei;Gong, Xiaoqing;Shi, Weichen;Shi, Lin;Shi, Lin

作者机构：

期刊名称：PHARMAZIE （ 影响因子：1.6； 五年影响因子：1.6 ）

ISSN： 0031-7144

年卷期： 2023 年 78 卷 1-4 期

页码：

收录情况： SCI

摘要： To explore potential indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors, we designed a series of compounds incorporating urea and 1,2,3-triazole structures. IDO1 enzymatic activity experiments with the synthesized compounds were used to verify their molecular-level activity; for instance, the half maximal inhibitory concentra-tion value of compound 3c was 0.07 mu M. Our research has yielded a series of novel IDO1 inhibitors which may be beneficial in the development of drugs targeting IDO1 for cancer treatment.

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