FGSE02, a Novel Secreted Protein in Fusarium graminearum FG-12, Leads to Cell Death in Plant Tissues and Modulates Fungal Virulence

文献类型： 外文期刊

第一作者： Hao, Zhigang

作者： Hao, Zhigang;Xu, Jiaqing;Yu, Chengxuan;Li, Jianqiang;Luo, Laixin;Hao, Zhigang;Hao, Zhigang;Li, Jianqiang;Luo, Laixin;Hao, Zhigang;Pan, Lei

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关键词： transcriptome; Fusarium graminearum; virulence-associated genes; effector protein

期刊名称：JOURNAL OF FUNGI （ 影响因子：4.0； 五年影响因子：4.5 ）

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年卷期： 2025 年 11 卷 5 期

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收录情况： SCI

摘要： Fungal phytopathogens employ effector proteins and secondary metabolites to subvert host immunity. Effector proteins have attracted widespread interest in infection, especially for unknown, unreported genes. However, the type of protein remains much less explored. Here, we combined transcriptome analysis and functional validation to identify virulence-associated genes in Fusarium graminearum during fungi infection. A unique secreted protein, FGSE02, was significantly upregulated in the early infection stage. Proteomic characterization revealed that the protein contains a functional signal peptide but lacks known domains. The transient expression of FGSE02 in Nicotiana benthamiana induced rapid cell death, while gene knockout stains reduced fungal virulence without affecting growth. Our findings highlight FGSE02 as a key virulence factor, offering potential targets for disease control. Taken together, the results of this study identify a pathogenic factor and provide new insights into the development of green pesticides.

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