Fabrication, characterization, and bioactivity of self-assembled carrier-free colloidal dispersions from Citrus x Limon 'Rosso' essential oil and tea polyphenols
文献类型： 外文期刊
第一作者： Cheng, Fangying
作者： Cheng, Fangying;Chen, Mianhong;Duan, Zhihao;Zou, Ying;He, Yunxia;Zeng, Fanke;Yuan, Yuan;Fu, Tiaokun;Tu, Hao;Li, Ruyi;Li, Jihua;Zhou, Wei;Cheng, Fangying;Duan, Zhihao
作者机构：
关键词： Tea polyphenols; Colloids; Self-assembly; Carrier-free nanodelivery system; Citrus x Limon 'Rosso' essential oil
期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）
ISSN： 0308-8146
年卷期： 2024 年 457 卷
页码：
收录情况： SCI
摘要： Carrier-free nanodelivery systems are fully self-assembled from active ingredients through interactions, offering the advantages of green, safe, and large-scale manufacturing. To improve the dispersion of Citrus x limon 'Rosso' peel essential oil (CEO) in water and boost the biological activity of CEO and tea polyphenols (TP), selfassembled CEO-TP colloidal dispersions (CEO-TP Colloids) were fabricated through sonication without surfactants or carriers. The optimal CEO and TP concentrations in the CEO-TP Colloids were determined to be 10.0 and 20.0 mg/mL by particle size and stability analyzer, respectively. The CEO self-assembled with TP to form spherical nanoparticles through hydrophobic and hydrogen-bonding interactions, whereas the CEO in CEO-TP Colloids weakened TP intramolecular aggregation. Meanwhile, the CEO-TP Colloids showed synergistic effects with better antibacterial, cellular antioxidant, and anti-inflammatory activities than single components. This study opens up the possibility of carrier-free co-delivery of hydrophobic and hydrophilic active components developed into food-grade formulations with multiple bioactivities.
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