Characterization of a New Insecticidal Benzothiazole Derivative from Aspergillus sp. 1022LEF against the Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)

文献类型： 外文期刊

第一作者： Yuan, Xiao-Long

作者： Yuan, Xiao-Long;Zhao, Dong-Lin;Zhang, Zhong-Feng;Ji, Gui-Xia;Chen, Dan;Zhang, Peng

作者机构：

关键词： fungal secondary metabolite; benzothiazole; insecticidal activity; Spodoptera frugiperda; biopesticides

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 50 期

页码：

收录情况： SCI

摘要： The fall armyworm Spodoptera frugiperda is considered one of the most destructive crop pests, posing a significant threat to food and crop security. In this study, we conducted a chemical investigation of the endophytic fungus Aspergillus sp. 1022LEF, leading to the identification of a previously unreported benzothiazole derivative, 6-(2-hydroxyethyl)benzo[d]thiazol-4-ol (HBT). Its structure was unambiguously characterized using extensive spectroscopic methods, including 1D and 2D NMR data, HRESIMS data, and single-crystal X-ray diffraction analysis. The insecticidal assay revealed that HBT possessed remarkable activity against S. frugiperda with an LC50 value of 0.24 mg/mL. Further transcriptomic and proteomic analyses revealed that HBT induced mortality in S. frugiperda by impeding DNA replication and protein synthesis, influencing mitochondria-mediated autophagy, and perturbing hormone synthesis, thereby disrupting the fundamental biosynthetic processes. HBT demonstrated high activity in controlling S. frugiperda, which highlighted its potential use as a lead in the development of biopesticides.

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