Neurotoxic effects of Cis-bifenthrin on microbe-gut-brain axis: Disruption of neurolipid balance in Xenopus laevis

文献类型： 外文期刊

第一作者： Li, Meng

作者： Li, Meng;Li, Chenxi;He, Mengai;Chen, Liezhong;Li, Meng;Wang, Qiangwei

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关键词： Cis -bifenthrin; Xenopus laevis; Neurolipid disorder; Microbe-gut-brain axis; Neurodegenerative diseases

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）

ISSN： 0147-6513

年卷期： 2025 年 302 卷

页码：

收录情况： SCI

摘要： The neurotoxic effects of cis-bifenthrin (cis-BF) on amphibians and its molecular mechanisms are unclear despite its common presence in aquatic environments. In present study, female Xenopus laevis were subjected to a threemonth treatment with environmentally relevant concentrations of 60 and 300 ng/L cis-BF. Metabolomic analysis of brain tissue revealed differential metabolites enriching bile acid (BA) synthesis, impacting beta-amyloid protein deposition. Reduced polyunsaturated fatty acids (PUFAs), essential for membrane integrity, were observed. Elevated amyloid beta-protein and lipopolysaccharide (LPS) levels suggested potential Alzheimer's-like symptoms induced by cis-BF. Given PUFAs and BAs are processed via enterohepatic circulation, a notable decrease in the abundance of genera linked to PUFAs and BAs metabolism was observed. Gut metabolomics revealed decreased concentrations of PUFAs and secondary BAs across cis-BF treatment groups, attributed to changes in associated microbial communities. Cis-BF exposure raised intestinal LPS levels and plasma proinflammatory cytokines, resulting in intestinal damage. This facilitated the entry of LPS into the bloodstream and brain tissue, indicating a cytokine-LPS interaction that promotes LPS transit to the brain through the bloodstream. Our study suggests that cis-BF-induced alterations in gut microbiota and metabolism may trigger Alzheimer's-related neurological disorders in Xenopus laevis via the gut-brain axis by inducing neurolipid disorder and inflammation.

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