The effects and mechanism of Aronia melanocarpa Elliot anthocyanins on hepatic fibrosis

文献类型： 外文期刊

第一作者： Yang, Jing

作者： Yang, Jing;Yu, Wenchen;Hao, Ruobing;Wei, Jie;Gao, Jun;Fan, Jungang

作者机构：

关键词： Aronia melanocarpa Elliot anthocyanins; Hepatic fibrosis; TGF-beta/Smad signaling pathway

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.223； 五年影响因子：5.178 ）

ISSN： 1756-4646

年卷期： 2020 年 68 卷

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收录情况： SCI

摘要： Hepatic fibrosis is a pathological change that is a major problem in chronic liver disease. As an important biologically active substance, the Aronia melanocarpa Elliot anthocyanins (AMA) has a strong anti-oxidation property and may have certain preventive and therapeutic effects on hepatic fibrosis diseases. The current research was designed for evaluation the antifibrotic effects and mechanism of AMA on CCl4-induced liver injury in mice. Mice injected with CCl4 twice a week at the same time as treated with 20 or 40 mg/kg AMA by gavage every day. After 8 weeks, biochemical parameters were used to estimate liver damage, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total serum bilirubin (TSB), total protein (TP) and albumin (ALB). In addition, oxidative stress parameters such as superoxide dismutase (SOD) and reduced glutathione (GSH) were also studied. And the role of TNF-alpha, IL-1, IL-6, COX-2 as markers of inflammation at the transcriptional level. Histopathological examination of liver tissue was performed and compared to controls. Collagen I, alpha smooth muscle actin (alpha-SMA), transforming growth factor beta 1 (TGF-beta 1) and SMAD2 were also evaluated as markers of fibrosis. The results showed that AMA improved CCl4-induced fibrosis, such as histopathological scores, markers of liver damage and oxidative stress. In addition, we investigated the potential mechanisms of underlying these effects, including: (1) inhibiting fibrosis by reducing the expression of inflammatory factors such as TNF-alpha and IL-1; (2) Prevent liver fibrosis by inactivating alpha-SMA expression; (3) inhibition of TGF-beta 1 secretion and Collagen I deposition to down-regulate the fiber reaction of HSC. In conclusion, this study illustrated the anti-fibrotic effects of AMA and may be a new candidate for the treatment of hepatic fibrosis.

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