Characterizing the hindgut microbiome in healthy and ketotic cows

文献类型： 外文期刊

第一作者： Ju, Zhihua

作者： Ju, Zhihua;Li, Rongling;Liu, Wenhao;Jiang, Qiang;Wang, Jinpeng;Zhang, Yaran;Wang, Xiuge;Xiao, Yao;Yang, Chunhong;Wei, Xiaochao;Gao, Yaping;Huang, Jinming;Ju, Zhihua;Li, Rongling;Liu, Wenhao;Wang, Jinpeng;Zhang, Yaran;Wang, Xiuge;Xiao, Yao;Huang, Jinming;Ju, Zhihua;Huang, Jinming

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关键词： Cow ketosis; beta-hydroxybutyrate; 16S sequencing; hindgut fecal microbiota

期刊名称：ALL LIFE （ 影响因子：1.0； 五年影响因子：1.0 ）

ISSN： 2689-5293

年卷期： 2024 年 17 卷 1 期

页码：

收录情况： SCI

摘要： Ketosis is a prevalent metabolic disease in the peripartum period of dairy cows, that causes considerable losses in milk production. In particular, the changes in the gut microbiome influence the occurrence of cow ketosis. In this study, the hindgut microbial communities of ketotic and healthy cows were compared and analyzed using 16S rRNA sequencing. Community composition analysis reveal that the predominant phyl in both groups were Bacteroidetes and Firmicutes. At the genus level, Bifidobacterium were more abundant in healthy cows than in ketotic cows. Conversely, the ketotic group exhibited a greater abundance of Bacteroides and Treponema than the healthy group. Differential hindgut fecal bacterial taxa in healthy and ketotic cows were identified by linear discriminant analysis effect size, with increases in Treponema, Bacteroides, and Peptococcaceae and decreases in Christensenellales, Chloroflexi, and Paenibacillaceae in ketotic cows. A distance-based redundancy analysis was conducted to further explore the connection between the gut microbiome, blood beta-hydroxybutyrate levels, and milk production traits. The results suggested that the hindgut microflora was significantly correlated with blood beta-hydroxybutyrate concentration and somatic cell score. These results improve our understanding of rectal microbes, and may help prevent ketosis in cows. Alterations in hindgut microbiota were associated with the occurrence of cow ketosis.The bacteria of Treponema, Bacteroides, and Peptococcaceae increased in the ketotic cows.The hindgut microflora were significantly correlated with blood BHB concentration.

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