Comparative proteomic analysis of subcutaneous and intraperitoneal cysts of Echinococcus multilocularis

文献类型： 外文期刊

第一作者： Zhang, Junmei

作者： Zhang, Junmei;Cao, Shanling;Tian, Zheng;Zhang, Zhengzhe;Zhou, Yu;Wu, Yixuan;Luo, Xuenong;Wang, Shuai;Guo, Xiaola;Wang, Shuai;Wang, Shuai;Guo, Xiaola

作者机构：

关键词： Alveolar echinococcosis; Echinococcus multilocularis; Intraperitoneal cysts; Subcutaneous cysts

期刊名称：JOURNAL OF PROTEOMICS （ 影响因子：2.8； 五年影响因子：3.0 ）

ISSN： 1874-3919

年卷期： 2025 年 320 卷

页码：

收录情况： SCI

摘要： Alveolar echinococcosis is a zoonotic disease that poses serious threats to public health. We observed subcutaneous cysts (SCs) of E. multilocularis had fewer protoscoleces (PSCs) compared to intraperitoneal cysts (ICs) at 60 days post-infection. However, the mechanisms underlying the development of E. multilocularis cysts in different tissues remain unclear. In this study, we compared the proteomic profiles of E. multilocularis cysts derived from mice intraperitoneally and subcutaneously infected with PSCs at 30 days post-infection, prior to the development of mature PSCs. Proteomic analysis identified 284 differentially expressed proteins (DEPs) in SCs compared to ICs, with 147 upregulated DEPs and 137 downregulated DEPs. Enzymatic proteins involved in carbohydrate and amino acid metabolism were predominantly upregulated in SCs compared to ICs, whereas proteins associated with protein folding, sorting, a degradation were downregulated. Western blotting analysis confirmed that phosphoenolpyruvate carboxykinase (PEPCK) and fructose-bisphosphate aldolase (FBA) were upregulated, whereas transitional endoplasmic reticulum ATPase (TER ATPase) was downregulated in SCs compared to ICs. The identified DEPs may play crucial roles in shaping the unique characteristics of E. multilocularis cysts. This study offers valuable insights into exploring the mechanisms underlying the occurrence and development of metacestodes.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序