Expression and Polymorphism of FSHR Gene in Sheep with Different Fecundity

文献类型： 外文期刊

第一作者： He, Xiaoyun

作者： He, Xiaoyun;Wang, Jinxin;Di, Ran;Liu, Qiuyue;Wang, Xiangyu;Hu, Wenping;Chu, Mingxing;La, Yongfu

作者机构：

关键词： FSHR gene; Polymorphism; Litter size; Hyplotype analysis; Hypothalamic-Pituitary-Gonadal Axis

期刊名称：PAKISTAN JOURNAL OF ZOOLOGY （ 影响因子：0.687； 五年影响因子：0.736 ）

ISSN： 0030-9923

年卷期： 2022 年 54 卷 2 期

页码：

收录情况： SCI

摘要： Follicle-stimulating hormone (FSH) is the pituitary hormone that regulates gonadal function by Hypothalamic-Pituitary-Gonadal Axis (HPGA) in vertebrates. FSHR has the function of transmitting follicle-stimulating growth biological information in animal breeding activities. In this study, we analyzed the structure of FSHR gene???s promoter, expression regulation and the correlation between polymorphism with fecundity. The results show that it is highly possible that the promoter of FSHR gene is in the region of 2045-2295bp and 2038-2288bp, TATA box was also found there. The expression differences were found in oviduct during every stage of estrous cycle (P<0.05) between Small Tail Han (STH) sheep and Tan (T) sheep. There were significant differences in genotype distribution between STH sheep and T sheep at T1235C and AG2357-2358 CT sites (P<0.01). The results of haplotypes analysis indicated that H2, H7 were preponderant haplotype in high prolificacy sheep breed. The litter size of TT genotype was significantly higher than that in CC genotype at T1235C loci in STH sheep (P<0.05). The current study provides evidence in sheep for genetic markers that might be used in breeding program.

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